- Abstract:
-
The over-expression of the islet amyloid polypeptide (IAPP) gene could be a causal factor for islet amyloidosis and beta-cell destruction in Type 2 diabetes (T2DM). An IAPP gene promoter polymorphism, IAPP-132G to A, has been associated with T2DM in Spain. To investigate this polymorphism in other cohorts and in relation to therapy, DNA from 425 T2DM and 279 unrelated, non-diabetic UK subjects (ND) and 102 T2DM and 80 ND Finnish subjects was examined. The relationship of amyloid severity (per...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bbadis.2005.02.001
-
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- Journal:
- Biochimica et biophysica acta
- Volume:
- 1740
- Issue:
- 1
- Pages:
- 74-78
- Publication date:
- 2005-04-05
- DOI:
- ISSN:
-
0006-3002
- URN:
-
uuid:8b3c876c-721b-4318-b05b-83d95c814ddf
- Source identifiers:
-
33089
- Local pid:
- pubs:33089
- Copyright date:
- 2005
Journal article
Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis.
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