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Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis.

Abstract:

The over-expression of the islet amyloid polypeptide (IAPP) gene could be a causal factor for islet amyloidosis and beta-cell destruction in Type 2 diabetes (T2DM). An IAPP gene promoter polymorphism, IAPP-132G to A, has been associated with T2DM in Spain. To investigate this polymorphism in other cohorts and in relation to therapy, DNA from 425 T2DM and 279 unrelated, non-diabetic UK subjects (ND) and 102 T2DM and 80 ND Finnish subjects was examined. The relationship of amyloid severity (per...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
Biochimica et biophysica acta
Volume:
1740
Issue:
1
Pages:
74-78
Publication date:
2005-04-05
DOI:
ISSN:
0006-3002
URN:
uuid:8b3c876c-721b-4318-b05b-83d95c814ddf
Source identifiers:
33089
Local pid:
pubs:33089

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