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Structure and dynamics of the gammaM4 transmembrane domain of the acetylcholine receptor in lipid bilayers: insights into receptor assembly and function.

Abstract:

A 28-mer peptide (gammaM4) corresponding to the fourth transmembrane segment of the nicotinic acetylcholine receptor (AChR) gamma-subunit, with a single tryptophan residue (Trp6), was reconstituted into lipid bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), loaded with either high or low amounts of cholesterol, i.e., in the conjugated liquid-ordered and liquid-disordered phases, respectively, at room temperature. By making use of the Trp intrinsic fluorescence, both steady...

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Publication status:
Published

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Publisher copy:
10.1080/09687860600703613

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Molecular membrane biology
Volume:
23
Issue:
4
Pages:
305-315
Publication date:
2006-01-01
DOI:
EISSN:
1464-5203
ISSN:
0968-7688
URN:
uuid:8b3b64c6-1155-4e57-b6d9-0235fe583efd
Source identifiers:
100452
Local pid:
pubs:100452

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