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Real-time surface-enhanced Raman spectroscopy monitoring of surface pH during electrochemical melting of double-stranded DNA.

Abstract:

The application of a negative potential ramp at a double-stranded DNA (dsDNA) functionalized electrode surface results in the gradual denaturation of the DNA in a process known as electrochemical melting. The underlying physical chemistry behind electrochemically driven DNA denaturation is not well understood, and one possible mechanism is a change in local pH at the electrode surface. We demonstrate that by coimmobilization of p-mercaptobenozic acid at a dsDNA-functionalized electrode surfac...

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Publication status:
Published

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Publisher copy:
10.1021/la204794g

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Langmuir : the ACS journal of surfaces and colloids
Volume:
28
Issue:
12
Pages:
5464-5470
Publication date:
2012-03-05
DOI:
EISSN:
1520-5827
ISSN:
0743-7463
URN:
uuid:8b3a1223-348d-486d-b16d-75649ecb0f6a
Source identifiers:
399983
Local pid:
pubs:399983

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