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The Role of histone and non-histone proteins in nuclear function

Abstract:

In eukaryotic cells, DNA, which contains the genetic information of the organism, is complexed with histones, a group of small, basic proteins of distinctive amino acid composition. Since the DNA of eukaryotes is mostly repressed, it was suggested by Stedman and Stedman, (1950, 1951) that the histones function as gene inhibitors. Unfortunately, the limited heterogeneity and comparative lack of tissue and species specificity (Panyim et al, 1971) of the histones is inadequate to explain the ...

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Peer review status:
Peer reviewed

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Department:
University of Oxford
Role:
Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8b1e1e90-76b1-438f-862b-58e1c6f3c304
Local pid:
polonsky:7:26
Source identifiers:
601870423
Deposit date:
2017-10-05

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