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Journal article

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Abstract:

The adaptation of animals to oxygen availability is mediated by a transcription factor termed hypoxia-inducible factor (HIF). HIF is an alpha (alpha)/beta (beta) heterodimer that binds hypoxia response elements (HREs) of target genes, including some of medicinal importance, such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF). While the concentration of the HIF-beta subunit, a constitutive nuclear protein, does not vary with oxygen availability, the abundance and activit...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Methods in enzymology More from this journal
Volume:
435
Pages:
25-42
Publication date:
2007-01-01
DOI:
EISSN:
1557-7988
ISSN:
0076-6879
Language:
English
Keywords:
Pubs id:
pubs:23963
UUID:
uuid:8b1d314d-95e8-40f9-9a42-85acb6c13ed5
Local pid:
pubs:23963
Source identifiers:
23963
Deposit date:
2012-12-19

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