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Journal article

High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.

Abstract:

Transforming growth factor-β (TGF-β) is an inducer of type I collagen, and uncontrolled collagen production leads to tissue scarring and organ failure. Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. For the first time, to our knowledge, we provide evidence that CUX1 acts as a negative regulator of TGF-β and potent inhibitor of type I collagen transcription. We show that CUX1, a CCAAT displaceme...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e10-08-0669

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Journal:
Molecular biology of the cell
Volume:
22
Issue:
11
Pages:
1836-1844
Publication date:
2011-06-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:8b1bdea0-3ff2-4584-8459-2593647a95df
Source identifiers:
223544
Local pid:
pubs:223544

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