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Journal article

Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae

Abstract:

Diphtheria is a respiratory disease caused by the bacterium Corynebacterium diphtheriae. Although the development of a toxin-based vaccine in the 1930s has allowed a high level of control over the disease, cases have increased in recent years. Here, we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories over 122 years. We generate a core gene phylogeny and determine the presence of antimicrobial resistance genes and variation within the tox gene o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-21870-5

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Role:
Author
ORCID:
0000-0002-4230-5182
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
1500
Publication date:
2021-03-08
Acceptance date:
2021-02-12
DOI:
EISSN:
2041-1723
Pmid:
33686077

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