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CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion.

Abstract:

Ciliary neurotrophic factor (CNTF) has been shown to protect ganglion cells in a variety of acute ischaemia models. Here we assess the efficacy of local CNTF gene transfer in protecting retinal ganglion cells when there is focal ischaemia combined with interruption of axoplasmic flow. This dual injury may be more representative of the pathological mechanisms operating in acute retinal diseases, such as vascular events acting at the optic nerve head. Fourteen rats received an intravitreal inje...

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Publication status:
Published

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Publisher copy:
10.1016/j.exer.2006.05.019

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
Experimental eye research More from this journal
Volume:
83
Issue:
5
Pages:
1118-1127
Publication date:
2006-11-01
DOI:
EISSN:
1096-0007
ISSN:
0014-4835
Language:
English
Keywords:
Pubs id:
pubs:95149
UUID:
uuid:8b17a80c-a8e6-4fba-a62b-a330f77791b6
Local pid:
pubs:95149
Source identifiers:
95149
Deposit date:
2012-12-19

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