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Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.

Abstract:

Invariant natural killer T (iNKT) cells are powerful immunomodulatory cells that in mice regulate a variety of immune responses, including acute GVHD (aGVHD). However, their clinical relevance and in particular their role in clinical aGVHD are not known. We studied whether peripheral blood stem cell (PBSC) graft iNKT-cell dose affects on the occurrence of clinically significant grade II-IV aGVHD in patients (n = 57) undergoing sibling, HLA-identical allogeneic HSCT. In multivariate analysis, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2011-11-389304

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Publisher:
American Society for Hematology
Journal:
Blood More from this journal
Volume:
119
Issue:
21
Pages:
5030-5036
Publication date:
2012-05-01
Acceptance date:
2012-02-16
DOI:
EISSN:
1528-0020
ISSN:
0006-4971

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