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Journal article

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

Abstract:

Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the heritable determination of gene expression. Using paired purified primary monocytes and B cells, we identify new predominantly cell type-specific cis and trans expression quantitative trait loci (eQTLs), including multi-locus trans associations to LYZ and KLF4 in monocytes and B cells, respectively. Additionally, we observe a B cell-specific trans association of rs11171739 at 12q13.2, a known autoimmune...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2205

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Journal:
Nature genetics
Volume:
44
Issue:
5
Pages:
502-510
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:8b0c2b51-456a-453c-9c4c-425374219ef8
Source identifiers:
320421
Local pid:
pubs:320421

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