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Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

Abstract:

Artemisinin derivatives and their partner drugs in artemisinin combination therapies (ACTs) have played a pivotal role in global malaria mortality reduction during the last two decades. The loss of artemisinin efficacy due to evolving drug-resistant parasites could become a serious global health threat. Dihydroartemisinin-piperaquine is a well tolerated and generally highly effective ACT. The implementation of a partner drug in ACTs is critical in the control of emerging artemisinin resistanc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ijpddr.2018.11.004

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Publisher:
Elsevier Publisher's website
Journal:
International Journal for Parasitology. Drugs and Drug Resistance Journal website
Volume:
9
Pages:
16-22
Publication date:
2018-12-01
Acceptance date:
2018-11-24
DOI:
EISSN:
2211-3207
ISSN:
2211-3207
Pubs id:
pubs:954677
URN:
uri:8b0786fe-9a95-41e1-b755-e01b79b2efb9
UUID:
uuid:8b0786fe-9a95-41e1-b755-e01b79b2efb9
Local pid:
pubs:954677

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