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The κB and V(D)J recombination signal sequence binding protein KRC regulates transcription of the mouse metastasis-associated gene S100A4/mts1

Abstract:

A κB-like sequence, Sb, is integral to the composite enhancer located in the first intron of the metastasis-associated gene, S100A4/mts1. Oligonucleotides containing this sequence form three specific complexes with nuclear proteins prepared from S100A4/mts1-expressing CSML100 adenocarcinoma cells. Protein studies show the Sb-interacting complexes include NF-κB/Rel proteins, p50·p50 and p50·p65 dimers. Additionally, the Sb sequence was bound by an unrelated ~200-kDa protein, p200. Site-directe...

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Publisher copy:
10.1074/jbc.275.2.913

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
Journal of Biological Chemistry
Volume:
275
Issue:
2
Pages:
913-920
Publication date:
2000-01-14
DOI:
ISSN:
0021-9258
URN:
uuid:8b0131f9-5d56-4974-9193-e887fb29a015
Source identifiers:
195134
Local pid:
pubs:195134

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