Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.

Journal article

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

Authors: Aziz, T; Peggs, D; Sambrook, M; Crossman, A

• Publication status: Published
• Journal: Movement disorders : official journal of the Movement Disorder Society
• Volume: 6
• Issue: 4
• Pages: 288-292
• Publication date: 1991-01-01
• DOI: 10.1002/mds.870060404
• EISSN: 1531-8257
• ISSN: 0885-3185
• Language: English
• Keywords: Brain Mapping; Dominance, Cerebral; Thalamic Nuclei; Animals; Radiosurgery; Parkinson Disease, Secondary; Macaca fascicularis; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Neurologic Examination