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Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms

Abstract:

Many investigators are now using haplotype-tagging single-nucleotide polymorphism (htSNPs) as a way of screening regions of the genome for association with disease. A common approach is to genotype htSNPs in a study population and to use this information to draw inferences about each individual's haplotypic makeup, including SNPs that were not directly genotyped. To test the validity of this approach, we simulated the exercise of typing htSNPs in a large sample of individuals and compared the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
"University of Oxford", "Tessella, Abingdon, UK"
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Funding agency for:
Gaia Luoni
Medical Research Council More from this funder
Publisher:
University of Chicago Press Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
76
Issue:
3
Pages:
438-448
Publication date:
2005-03-05
ISSN:
0002-9297
URN:
uuid:8afb07bb-89b1-4d04-b40d-35d568607cbb
Local pid:
ora:1391

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