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Exploring neuroinflammatory processes in a mouse model of amyotrophic lateral sclerosis

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease, affecting both upper and lower motor neurons in the CNS. Around 10% of ALS cases are classed as familial, and around 20% of these are due to a mutation in the gene superoxide dismutase-1 (SOD1). The SOD1G93A mouse is one of the transgenic rodent models of this disease. Both in humans and animal models of ALS, neuroinflammation is an important theme that has attracted much research attention ove...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Magdalen College
Department:
Medical Sciences Division - Clinical Neurology
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Funding agency for:
Matthew C Evans
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral

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