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Ancient evolutionary origin of the neural crest gene regulatory network.

Abstract:

The vertebrate neural crest migrates from its origin, the neural plate border, to form diverse derivatives. We previously hypothesized that a neural crest gene regulatory network (NC-GRN) guides neural crest formation. Here, we investigate when during evolution this hypothetical network emerged by analyzing neural crest formation in lamprey, a basal extant vertebrate. We identify 50 NC-GRN homologs and use morpholinos to demonstrate a critical role for eight transcriptional regulators. The re...

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Journal:
Developmental cell
Volume:
13
Issue:
3
Pages:
405-420
Publication date:
2007-09-01
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Source identifiers:
257488

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