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A simple desymmetrisation approach to unsymmetric N,N '-disubstituted cyclic ureas

Abstract:
The bis-enolate derived from 1,3-di-isobutyryl-trans-4,5-tetramethylene- imidazolidin-2-one 8 is unstable and deacylates to afford dianion 11 which can be regioselectively alkylated to afford unsymmetric cyclic urea 17 in good yield. Subsequent deacylation of 17 and methylation on nitrogen affords unsymmetric 1-benzyl-3-methyltrans-4,5-tetramethyleneimidazolidin-2-one 19 in good yield.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
40
Issue:
39
Pages:
7143-7146
Publication date:
1999-09-24
DOI:
ISSN:
0040-4039
Language:
English
Pubs id:
pubs:110615
UUID:
uuid:8aea37fd-7579-4843-addf-a8d5672c2879
Local pid:
pubs:110615
Source identifiers:
110615
Deposit date:
2012-12-19

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