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SPET imaging of central muscarinic receptors with (R,R)[123I]-I-QNB: methodological considerations.

Abstract:

Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-I-QNB indicates this ligand has selectivity for m(1) and m(4) muscarinic receptor subtypes. Therefore, we used (R,R)[(123)I]-I...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
Nuclear medicine and biology More from this journal
Volume:
31
Issue:
5
Pages:
583-590
Publication date:
2004-07-01
DOI:
EISSN:
1872-9614
ISSN:
0969-8051

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