SPET imaging of central muscarinic receptors with (R,R)[123I]-I-QNB: methodological considerations.

Journal article

Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-I-QNB indicates this ligand has selectivity for m(1) and m(4) muscarinic receptor subtypes. Therefore, we used (R,R)[(123)I]-I...

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Authors: Norbury, R; Travis, M; Erlandsson, K; Waddington, W; Owens, J

• Publication status: Published
• Journal: Nuclear medicine and biology
• Volume: 31
• Issue: 5
• Pages: 583-590
• Publication date: 2004-07-01
• DOI: 10.1016/j.nucmedbio.2004.01.003
• EISSN: 1872-9614
• ISSN: 0969-8051
• Language: English
• Keywords: Quinuclidinyl Benzilate; Receptor, Muscarinic M4; Radiopharmaceuticals; Sensitivity and Specificity; Middle Aged; Aged; Aging; Brain; Tissue Distribution; Reproducibility of Results; Aged, 80 and over; Receptor, Muscarinic M1; Image Interpretation, Computer-Assisted; Humans; Tomography, Emission-Computed, Single-Photon; Adult; Female; Age Factors