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Dynamical modeling of syncytial mitotic cycles in Drosophila embryos.

Abstract:

Immediately following fertilization, the fruit fly embryo undergoes 13 rapid, synchronous, syncytial nuclear division cycles driven by maternal genes and proteins. During these mitotic cycles, there are barely detectable oscillations in the total level of B-type cyclins. In this paper, we propose a dynamical model for the molecular events underlying these early nuclear division cycles in Drosophila. The model distinguishes nuclear and cytoplasmic compartments of the embryo and permits explora...

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Publication status:
Published

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Publisher copy:
10.1038/msb4100171

Authors


Calzone, L More by this author
Thieffry, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Molecular systems biology
Volume:
3
Pages:
131
Publication date:
2007
DOI:
EISSN:
1744-4292
ISSN:
1744-4292
URN:
uuid:8ad4a816-3c8f-42ee-8dd6-96f1d5037bdb
Source identifiers:
100409
Local pid:
pubs:100409

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