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Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates.

Abstract:

To prevent important infectious diseases such as tuberculosis, malaria and HIV, vaccines inducing greater T cell responses are required. In this study, we investigated whether fusion of the M. tuberculosis antigen 85A to recently described adjuvant IMX313, a hybrid avian C4bp oligomerization domain, could increase T cell responses in pre-clinical vaccine model species. In mice, the fused antigen 85A showed consistent increases in CD4(+) and CD8(+) T cell responses after DNA and MVA vaccinatio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0033555

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Foundation for the National Institute of Health, Grand Challenges in Global Health Initiative More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
3
Pages:
Article: e33555
Publication date:
2012
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:8ad44466-e47f-4258-a861-2a0107e8a0b6
Source identifiers:
322672
Local pid:
pubs:322672

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