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Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial.

Abstract:

BACKGROUND: Previous studies of patients with chronic lymphocytic leukaemia reported high response rates to fludarabine combined with cyclophosphamide. We aimed to establish whether this treatment combination provided greater survival benefit than did chlorambucil or fludarabine. METHODS: 777 patients with chronic lymphocytic leukaemia requiring treatment were randomly assigned to fludarabine (n=194) or fludarabine plus cyclophosphamide (196) for six courses, or chlorambucil (387) for 12 cour...

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Publication status:
Published

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Authors


Catovsky, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Matutes, E More by this author
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Journal:
Lancet
Volume:
370
Issue:
9583
Pages:
230-239
Publication date:
2007-07-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:8ad12c2e-d4a9-4d75-aaa1-63fd270f5f96
Source identifiers:
66730
Local pid:
pubs:66730

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