Journal article
Enantiomerically enriched tetrahydropyridine allyl chlorides
- Abstract:
-
Enantiomerically enriched allyl halides are rare due to their configurational lability. Here we report stable piperidine-based allyl chloride enantiomers. These allyl chlorides can be produced via kinetic resolution, and undergo highly enantiospecific catalyst-free substitution reactions with C, N, O and S-based nucleophiles. DFT calculations and experiments with deuterium-labelled chloro-tetrahydropyridine, selectively prepared using H/D primary kinetic isotope effect, were used to investiga...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 11
- Issue:
- 16
- Pages:
- 4125-4130
- Publication date:
- 2020-04-01
- Acceptance date:
- 2020-03-24
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1097915
- Local pid:
- pubs:1097915
- Deposit date:
- 2020-07-30
Terms of use
- Copyright holder:
- Karabiyikoglu, S et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Karabiyikoglu, S et al. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
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