Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Journal article

The major known genetic risk factors in multiple sclerosis reside in the major histocompatibility complex (MHC) region. Although there is strong evidence implicating MHC class II alleles and CD4(+) T cells in multiple sclerosis pathogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial. We have generated humanized mice expressing the multiple sclerosis-associated MHC class I alleles HLA-A(*)0301 (encoding human leukocyte antigen-A3 (HLA-A3)) and HLA-A(*)0...

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Authors: Friese, M; Jakobsen, K; Friis, L; Etzensperger, R; Craner, M

• Publication status: Published
• Journal: Nature medicine
• Volume: 14
• Issue: 11
• Pages: 1227-1235
• Publication date: 2008-11-01
• DOI: 10.1038/nm.1881
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: CD4-Positive T-Lymphocytes; Gene Expression Regulation; Multiple Sclerosis; Animals; Central Nervous System; Thymus Gland; Mice, Transgenic; CD8-Positive T-Lymphocytes; Mice; Humans; Histocompatibility Antigens Class I; Receptors, Antigen, T-Cell