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Journal article

Alveolar macrophage apoptosis-associated bacterial killing helps prevent murine pneumonia

Abstract:

RATIONALE: Antimicrobial resistance challenges therapy of pneumonia. Enhancing macrophage microbicidal responses would combat this problem but is limited by our understanding of how alveolar macrophages (AM) kill bacteria.

OBJECTIVES: To define the role and mechanism of AM apoptosis-associated bacterial killing in the lung.

METHODS: We generated a unique CD68.hMcl-1 transgenic mouse with macrophage-specific over-expression of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1164/rccm.201804-0646oc

Authors


More from this funder
Name:
Medical Research Council
Grant:
MR/M017931/1
More from this funder
Name:
British Heart Foundation
Grant:
RG/15/10/31485
Publisher:
American Thoracic Society
Journal:
American Journal of Respiratory and Critical Care Medicine More from this journal
Volume:
200
Issue:
1
Pages:
84–97
Publication date:
2019-01-16
Acceptance date:
2019-01-14
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
Pmid:
30649895
Language:
English
Keywords:
Pubs id:
pubs:966083
UUID:
uuid:8ac9794a-3595-4c0c-b77a-a383c4ad1ddb
Local pid:
pubs:966083
Source identifiers:
966083
Deposit date:
2019-06-18

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