Journal article
Proteome-wide analysis of HIV-specific naive and memory CD4(+) T cells in unexposed blood donors.
- Abstract:
-
The preexisting HIV-1-specific T cell repertoire must influence both the immunodominance of T cells after infection and immunogenicity of vaccines. We directly compared two methods for measuring the preexisting CD4(+) T cell repertoire in healthy HIV-1-negative volunteers, the HLA-peptide tetramer enrichment and T cell library technique, and show high concordance (r = 0.989). Using the library technique, we examined whether naive, central memory, and/or effector memory CD4(+) T cells specific...
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- Publication status:
- Published
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- Publisher copy:
- 10.1084/jem.20130555
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Authors
Bibliographic Details
- Publisher:
- Rockefeller University Press
- Journal:
- Journal of experimental medicine
- Volume:
- 211
- Issue:
- 7
- Pages:
- 1273-1280
- Publication date:
- 2014-06-01
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- Source identifiers:
-
471272
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:471272
- UUID:
-
uuid:8ac77708-af53-436d-9d34-ff1fa1ee975a
- Local pid:
- pubs:471272
- Deposit date:
- 2014-07-23
Terms of use
- Copyright date:
- 2014
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