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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Abstract:

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ng.3654

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
48
Issue:
10
Pages:
1151–1161
Publication date:
2016-09-12
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:644397
URN:
uri:8ac1e907-a3d3-41e3-90b2-5dfd084d9c0c
UUID:
uuid:8ac1e907-a3d3-41e3-90b2-5dfd084d9c0c
Local pid:
pubs:644397
Paper number:
10

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