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Genetic determinants of jaundice and gallstones in haemoglobin E beta thalassaemia.

Abstract:

Chronic hyperbilirubinaemia, gallstone formation, and gall bladder disease are unusually common in people with haemoglobin E beta thalassaemia in Sri Lanka. To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene. There was a significantly higher bilirubin level in those with the 7/7 genotypes compared with 6/6 and 6/7 genotype (p=0.032 and 0.0015 respectively), who also appeared more prone...

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Publication status:
Published

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Journal:
Lancet More from this journal
Volume:
357
Issue:
9272
Pages:
1945-1946
Publication date:
2001-06-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Language:
English
Keywords:
Pubs id:
pubs:196437
UUID:
uuid:8abc5d44-3800-432d-91e7-7a9c39ca7284
Local pid:
pubs:196437
Source identifiers:
196437
Deposit date:
2012-12-19

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