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NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca2+/ calmodulin-dependent kinases

Abstract:

Long-term potentiation (LTP) of excitatory synaptic transmission plays a major role in memory encoding in the cerebral cortex. It can be elicited at many synapses on principal cells, where it depends on Ca2+ influx through postsynaptic N-methyl-d-aspartic acid (NMDA) receptors. Ca2+ influx triggers phosphorylation of several kinases, in particular Ca2+/calmodulin-dependent kinase type II (CaMKII). Auto-phosphorylation of CaMKII is a key step in the LTP induction cascade, as revealed by the ab...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Journal of Physiology More from this journal
Volume:
584
Issue:
3
Pages:
885-894
Publication date:
2007-11-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pubs id:
pubs:222069
UUID:
uuid:8aba4bab-cae9-4072-8025-71cfce6abc60
Local pid:
pubs:222069
Source identifiers:
222069
Deposit date:
2012-12-19

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