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Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor-growths

Abstract:

A significant proportion of ATP fuels the removal of metabolic end-products, particularly H+ ions which profoundly affect biological activities. Since energetic resources in hypoxic tumor-regions are constrained by low-yielding glycolysis, any means of reducing the cost of acid-extrusion, without compromising pH homeostasis, would be advantageous. Some cancers express connexin channels for allowing solute exchange, and we propose that, via this route, normoxic cells supply hypoxic neighbors w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1096/fj.201700480R

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Niederer, SA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Corpus Christi College
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Grant:
IONTRAC Marie Curie Initial Training Network (FP7-PEOPLE-2011-ITN Grant 289648)
Royal Society More from this funder
Publisher:
Federation of American Society of Experimental Biology Publisher's website
Journal:
FASEB Journal Journal website
Volume:
32
Issue:
1
Pages:
83-96
Publication date:
2017-09-07
Acceptance date:
2017-08-14
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Pubs id:
pubs:714162
URN:
uri:8ab6f615-6824-4a6c-8c98-8c04185ea58c
UUID:
uuid:8ab6f615-6824-4a6c-8c98-8c04185ea58c
Local pid:
pubs:714162

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