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Journal article

Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan.

Abstract:

BACKGROUND: Local cardiac renin-angiotensin systems may regulate left ventricular (LV) hypertrophic responses. The absence (deletion [D]) of a 287-bp marker in the ACE gene is associated with greater myocardial ACE levels and exercise-related LV growth than is its presence (insertion [I]), an effect potentially mediated through either increased activity of the cellular growth factor angiotensin II on the angiotensin type 1 (AT(1)) receptor or increased degradation of growth-inhibiting kinins....

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Publication status:
Published

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Publisher copy:
10.1161/01.cir.103.2.226

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation
Volume:
103
Issue:
2
Pages:
226-230
Publication date:
2001-01-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
105109
Language:
English
Keywords:
Pubs id:
pubs:105109
UUID:
uuid:8ab31f9a-9de0-4cf9-9303-f92a93c40157
Local pid:
pubs:105109
Deposit date:
2012-12-19

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