Pattern of impaired working memory during major depression.

Journal article

BACKGROUND: The aim of this study was to assess working memory (WM) in patients with major depressive disorder (MDD), using a robust parametric WM task (the n-back task). METHODS: Twenty patients with MDD and twenty healthy controls completed a visual version of the paradigm, comprising four levels of task difficulty (i.e. 0-, 1-, 2-, and 3-back). Performance accuracy and reaction time (RT) were measured at each difficulty level. RESULTS: In comparison with controls, patients with MDD exhibit...

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Authors: Rose, E; Ebmeier, K

• Publication status: Published
• Journal: Journal of affective disorders
• Volume: 90
• Issue: 2-3
• Pages: 149-161
• Publication date: 2006-02-01
• DOI: 10.1016/j.jad.2005.11.003
• EISSN: 1573-2517
• ISSN: 0165-0327
• Language: English
• Keywords: Depressive Disorder, Major; Adult; Attention; Psychometrics; Personality Inventory; Case-Control Studies; Orientation; Neuropsychological Tests; Statistics as Topic; Female; Male; Cognition Disorders; Serial Learning; Humans; Pattern Recognition, Visual; Memory, Short-Term; Middle Aged; Reaction Time