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Journal article

Impact of intended and relative dose intensity of R‐CHOP in a large, consecutive cohort of elderly diffuse large B‐cell lymphoma patients treated with curative intent: no difference in cumulative incidence of relapse comparing patients by age

Abstract:

BACKGROUND:The increasing incidence of DLBCL in aging populations places a significant burden on healthcare systems. Co-morbidity, frailty, and reduced organ and physiological reserve contribute to treatment-related complications. The optimal dose intensity of R-CHOP to optimise outcome across different ages with variable frailty and comorbidity burden is unclear OBJECTIVES AND METHODS: We examined the influence of intended (IDI) and relative (RDI) dose intensity of the combination of cycloph...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/joim.12889

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-5095-6367
Publisher:
Wiley
Journal:
Journal of Internal Medicine More from this journal
Publication date:
2019-04-11
Acceptance date:
2019-02-27
DOI:
EISSN:
1365-2796
ISSN:
0954-6820
Pmid:
30811713
Language:
English
Keywords:
Pubs id:
pubs:978361
UUID:
uuid:8aa7db48-d66a-4ccb-93ab-017966bef5bd
Local pid:
pubs:978361
Deposit date:
2019-05-20

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