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Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result?

Abstract:

Prior hypotheses in functional brain imaging are often formulated by constraining the data analysis to regions of interest (ROIs). In this context, this approach yields higher sensitivity than whole brain analyses, which could be particularly important in drug development studies and clinical decision making. Here we systematically examine the effects of different ROI definition criteria on the results inferred from a hypothesis-driven pharmacological fMRI experiment, with the aim of maximisi...

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Publication status:
Published

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Authors


Mitsis, GD More by this author
Iannetti, GD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
NeuroImage
Volume:
40
Issue:
1
Pages:
121-132
Publication date:
2008-03-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:8aa0a39b-32aa-4ac0-8d3b-aa80e027ae66
Source identifiers:
242002
Local pid:
pubs:242002

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