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Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result?

Abstract:

Prior hypotheses in functional brain imaging are often formulated by constraining the data analysis to regions of interest (ROIs). In this context, this approach yields higher sensitivity than whole brain analyses, which could be particularly important in drug development studies and clinical decision making. Here we systematically examine the effects of different ROI definition criteria on the results inferred from a hypothesis-driven pharmacological fMRI experiment, with the aim of maximisi...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
NeuroImage
Volume:
40
Issue:
1
Pages:
121-132
Publication date:
2008-03-01
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Source identifiers:
242002
Language:
English
Keywords:
Pubs id:
pubs:242002
UUID:
uuid:8aa0a39b-32aa-4ac0-8d3b-aa80e027ae66
Local pid:
pubs:242002
Deposit date:
2012-12-19

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