Journal article icon

Journal article

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression

Abstract:

Objectives To identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 promoter, with ankylosing spondylitis (AS).

Methods We performed conditional analysis of genetic association data and used ENCODE data on chromatin remodelling and transcription factor (TF) binding sites to identify the primary AS-associated regulatory SNP in the RUNX3 region. The functional effects of this SNP wer...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1136/annrheumdis-2015-207490

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Roberts, AR
Grant:
20402
National Institute for Health Research More from this funder
National Ankylosing Spondylitis Society More from this funder
Arthritis Research UK More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Annals of the Rheumatic Diseases Journal website
Volume:
75
Issue:
8
Pages:
1534-1540
Publication date:
2015-10-09
Acceptance date:
2015-08-19
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Source identifiers:
568739
Language:
English
Pubs id:
pubs:568739
UUID:
uuid:8a9ba3ab-6ee4-4df0-a1ee-1c73687dcb0a
Local pid:
pubs:568739
Deposit date:
2015-10-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP