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Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Abstract:

Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. Here, we have developed a novel functional genomics methodology to express common locus haplotypes to assess functional differences. DNA recombination was used to engineer 5 bacterial artificial chromosomes (BACs) to each express a different haplotype of the NCSTN locus. Each NCSTN-BAC was delivered to knockout nicastrin (Ncstn(-/-)) cells and clonal NCSTN-BAC(+...

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Publication status:
Published

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Journal:
Neurobiology of aging More from this journal
Volume:
33
Issue:
8
Pages:
1848.e1-1848.13
Publication date:
2012-08-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580

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