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Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate

Abstract:

Hyperpolarised 13C MRI can be used to generate metabolic images of the heart in vivo. However, there have been no similar studies performed in the isolated perfused heart. Therefore, the aim of this study was to develop a method for the creation of 13C metabolite maps of the perfused rat heart and to demonstrate the technique in a study of acute and chronic myocardial infarction. Male Wistar rat hearts were isolated, perfused and imaged before and after occlusion of the left anterior descendi...

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Publisher copy:
10.1002/nbm.2972

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
NMR in Biomedicine
Volume:
26
Issue:
11
Pages:
1441-1450
Publication date:
2013-11-01
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Source identifiers:
436634
Language:
English
Keywords:
Pubs id:
pubs:436634
UUID:
uuid:8a8e9c73-b4db-4447-b98d-9f9b82c419a5
Local pid:
pubs:436634
Deposit date:
2013-12-13

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