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Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra.

Abstract:

The exact mechanism of cell death in neurodegenerative diseases remains obscure, although there is evidence that their pathogenesis may involve the formation of free radicals originating from the oxidative metabolism of catecholamines. The purpose of this study was to evaluate the degree of neurodegenerative changes and behavioral impairments induced by unilateral injection into the rat substantia nigra of cyclized o-quinones, aminochrome and dopachrome, derived from oxidizing dopamine and L-...

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Authors


Díaz-Véliz, G More by this author
Arriagada, C More by this author
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Journal:
Pharmacology, biochemistry, and behavior
Volume:
73
Issue:
4
Pages:
843-850
Publication date:
2002-11-05
DOI:
EISSN:
1873-5177
ISSN:
0091-3057
URN:
uuid:8a8cb77a-cce8-4ea4-84fc-465bfe3b980a
Source identifiers:
425174
Local pid:
pubs:425174

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