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Disease-associated risk variants in ANRIL are associated with tumor-infiltrating lymphocyte presence in primary melanomas in the population-based GEM study

Abstract:
Background: Genome-wide association studies have reported that genetic variation at ANRIL (CDKN2B-AS1) is associated with risk of several chronic diseases including coronary artery disease, coronary artery calcification, myocardial infarction, and type 2 diabetes mellitus. ANRIL is located at the CDKN2A/B locus, which encodes multiple melanoma tumor suppressors. We investigated the association of these variants with melanoma prognostic characteristics.
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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1055-9965.epi-21-0686

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Role:
Author
ORCID:
0000-0001-6738-9418
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Role:
Author
ORCID:
0000-0001-6234-6961
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Role:
Author
ORCID:
0000-0002-5567-9618
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Role:
Author
ORCID:
0000-0001-8273-446X
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Name:
HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute
Publisher:
American Association for Cancer Research
Journal:
Cancer Epidemiology, Biomarkers and Prevention More from this journal
Volume:
30
Issue:
12
Pages:
2309-2316
Publication date:
2021-10-04
Acceptance date:
2021-09-23
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
Pmid:
34607836
Language:
English
Keywords:
Pubs id:
1199471
Local pid:
pubs:1199471
Deposit date:
2021-11-08

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