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Journal article

Universal alternative splicing of noncoding exons

Abstract:

The human transcriptome is so large, diverse, and dynamic that, even after a decade of investigation by RNA sequencing (RNA-seq), we have yet to resolve its true dimensions. RNA-seq suffers from an expression-dependent bias that impedes characterization of low-abundance transcripts. We performed targeted single-molecule and short-read RNA-seq to survey the transcriptional landscape of a single human chromosome (Hsa21) at unprecedented resolution. Our analysis reaches the lower limits of the t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
National Health and Medical Research Council
Grant:
APP1072662
More from this funder
Name:
EMBO
Grant:
ALTF 864-2013
Publisher:
Cell Press
Journal:
Cell Systems More from this journal
Volume:
6
Issue:
2
Pages:
245-255.e5
Publication date:
2018-01-24
Acceptance date:
2017-12-08
DOI:
EISSN:
2405-4712
ISSN:
2405-4720
Pmid:
29396323
Language:
English
Keywords:
Pubs id:
pubs:823019
UUID:
uuid:8a772fc2-c5dd-4bdb-9be1-4a92cffaf142
Local pid:
pubs:823019
Source identifiers:
823019
Deposit date:
2018-02-10

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