Journal article icon

Journal article

Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease.

Abstract:

Dent's disease, which is a renal tubular disorder characterized by low molecular weight proteinuria, hypercalciuria and nephrolithiasis, is associated with inactivating mutations of the X-linked chloride channel, CLC-5. However, the manner in which a functional loss of CLC-5 leads to such diverse renal abnormalities remains to be defined. In order to elucidate this, we performed studies to determine the segmental expression of CLC-5 in the human kidney and to define its intracellular distribu...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/8.2.247

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Publisher:
Oxford University Press
Journal:
Human molecular genetics
Volume:
8
Issue:
2
Pages:
247-257
Publication date:
1999-02-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
1754

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP