Journal article
Role of cholesterol metabolism in the anticancer pharmacology of selective estrogen receptor modulators
- Abstract:
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Selective estrogen receptor modulators (SERMs) are a class of compounds that bind to estrogen receptors (ERs) and possess estrogen agonist or antagonist actions in different tissues. As such, they are widely used drugs. For instance, tamoxifen, the most prescribed SERM, is used to treat ERα-positive breast cancer. Aside from their therapeutic targets, SERMs have the capacity to broadly affect cellular cholesterol metabolism and handling, mainly through ER-independent mechanisms. Cholesterol m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Accepted manuscript, 492.3KB)
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- Publisher copy:
- 10.1016/j.semcancer.2020.08.015
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Seminars in Cancer Biology Journal website
- Volume:
- 73
- Pages:
- 101-115
- Publication date:
- 2020-09-12
- Acceptance date:
- 2020-08-26
- DOI:
- EISSN:
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1096-3650
- ISSN:
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1044-579X
- Pmid:
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32931953
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1134888
- Local pid:
- pubs:1134888
- Deposit date:
- 2021-07-13
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Ltd. All rights reserved.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from Elsevier at https://doi.org/10.1016/j.semcancer.2020.08.015
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