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Effective targeting of the tumor microenvironment for cancer therapy.

Abstract:

BACKGROUND: The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan hyaluronan (HA) accumulates in 20-30% of tumors and is often associated with poor prognosis. MATERIALS AND METHODS: We developed a digitized, semiquantitative scoring system for tumor-associated HA content, then grouped tumors (from animal models or patients) according to the degree of HA accumulation (HA+1,2,3). The antitumor response to HA-depletion by pegylated PH20 h...

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Publication status:
Published

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Authors


Thompson, CB More by this author
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Journal:
Anticancer research
Volume:
32
Issue:
4
Pages:
1203-1212
Publication date:
2012-04-05
EISSN:
1791-7530
ISSN:
0250-7005
URN:
uuid:8a6928fa-9b0c-4fda-a6f2-3284e1e94f48
Source identifiers:
323047
Local pid:
pubs:323047

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