Journal article
Effective targeting of the tumor microenvironment for cancer therapy.
- Abstract:
-
BACKGROUND: The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan hyaluronan (HA) accumulates in 20-30% of tumors and is often associated with poor prognosis. MATERIALS AND METHODS: We developed a digitized, semiquantitative scoring system for tumor-associated HA content, then grouped tumors (from animal models or patients) according to the degree of HA accumulation (HA+1,2,3). The antitumor response to HA-depletion by pegylated PH20 h...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Anticancer research
- Volume:
- 32
- Issue:
- 4
- Pages:
- 1203-1212
- Publication date:
- 2012-04-05
- EISSN:
-
1791-7530
- ISSN:
-
0250-7005
- URN:
-
uuid:8a6928fa-9b0c-4fda-a6f2-3284e1e94f48
- Source identifiers:
-
323047
- Local pid:
- pubs:323047
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- Copyright date:
- 2012
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