Conference icon

Conference

Incorporating variability and uncertainty into interspecies scaling of pharmacokinetics

Abstract:

A Monte Carlo simulation procedure for incorporating measures of the variability and uncertainty into the prediction of pharmacokinetics is presented. The approach is validated by a Monte-Carlo simulation of the prediction of the in vivo rat intrinsic clearance from in vitro (microsomal and hepatocyte) data for eight benzodiazepine drugs. For most of the drugs a significant overlap of the confidence regions with the line of unity exists. Therefore, the hypothesis, that the scaled intrinsic cl...

Expand abstract
Publication status:
Published

Actions


Authors


Pages:
97-102
Publication date:
2000-01-01
URN:
uuid:8a663f23-3320-46cd-970f-f46600fe8e24
Source identifiers:
19204
Local pid:
pubs:19204
ISBN:
0-08-043549-1

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP