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Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.

Abstract:

Specialized B cells residing in the splenic marginal zone (MZ) continuously survey the blood for antigens and are important for immunity to systemic infections. However, the cues that uniquely attract cells to the MZ have not been defined. Previous work demonstrated that mice deficient in cannabinoid receptor 2 (CB2) have decreased numbers of MZ B cells but it has been unclear whether CB2 regulates MZ B cell development or positioning. We show that MZ B cells are highly responsive to the CB2 ...

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Publisher copy:
10.1084/jem.20111083

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The Journal of experimental medicine
Volume:
208
Issue:
10
Pages:
1941-1948
Publication date:
2011-09-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:8a5eaa9d-8498-4144-a06c-92eadb14845e
Source identifiers:
482813
Local pid:
pubs:482813

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