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Journal article

beta-Sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes.

Abstract:

The disruption of intracellular calcium homeostasis plays a central role in the pathology of Alzheimer's disease, which is also characterized by accumulation of the amyloid-beta peptides Abeta40 and Abeta42. These amphipathic peptides may become associated with neuronal membranes and affect their barrier function, resulting in the loss of calcium homeostasis. This suggestion has been extensively investigated by exposing protein-free model membranes, either vesicles or planar bilayers, to solu...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2007.02.063

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Journal:
Journal of molecular biology
Volume:
368
Issue:
4
Pages:
982-997
Publication date:
2007-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:8a5c1d19-67db-4028-8ed8-80195bc6cf81
Source identifiers:
21825
Local pid:
pubs:21825

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