Journal article
beta-Sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes.
- Abstract:
-
The disruption of intracellular calcium homeostasis plays a central role in the pathology of Alzheimer's disease, which is also characterized by accumulation of the amyloid-beta peptides Abeta40 and Abeta42. These amphipathic peptides may become associated with neuronal membranes and affect their barrier function, resulting in the loss of calcium homeostasis. This suggestion has been extensively investigated by exposing protein-free model membranes, either vesicles or planar bilayers, to solu...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.jmb.2007.02.063
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Authors
Bibliographic Details
- Journal:
- Journal of molecular biology
- Volume:
- 368
- Issue:
- 4
- Pages:
- 982-997
- Publication date:
- 2007-05-01
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- Source identifiers:
-
21825
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:21825
- UUID:
-
uuid:8a5c1d19-67db-4028-8ed8-80195bc6cf81
- Local pid:
- pubs:21825
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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