- Abstract:
-
The disruption of intracellular calcium homeostasis plays a central role in the pathology of Alzheimer's disease, which is also characterized by accumulation of the amyloid-beta peptides Abeta40 and Abeta42. These amphipathic peptides may become associated with neuronal membranes and affect their barrier function, resulting in the loss of calcium homeostasis. This suggestion has been extensively investigated by exposing protein-free model membranes, either vesicles or planar bilayers, to solu...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmb.2007.02.063
-
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- Journal:
- Journal of molecular biology
- Volume:
- 368
- Issue:
- 4
- Pages:
- 982-997
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:8a5c1d19-67db-4028-8ed8-80195bc6cf81
- Source identifiers:
-
21825
- Local pid:
- pubs:21825
- Copyright date:
- 2007
Journal article
beta-Sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes.
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