NSO myeloma cell death: Influence of bcl-2 overexpression.

Journal article

The productivity of recombinant mammalian cell lines growth in batch culture is often limited by the rapidity with which cells die on entry into the decline phase (the period of culture after the maximum cell density has been reached and where cell viability begins to fall). We examined the decline phase characteristics of the NSO myeloma cell line with a view to modulating the cell death that ensues. Examination of nuclear morphology during culture revealed that the onset of the decline phas...

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Authors: Murray, K; Ang, C; Gull, K; Hickman, J; Dickson, A

• Publication status: Published
• Journal: Biotechnology and bioengineering
• Volume: 51
• Issue: 3
• Pages: 298-304
• Publication date: 1996-08-01
• DOI: 10.1002/(sici)1097-0290(19960805)51:3<298::aid-bit5>3.0.co;2-8
• EISSN: 1097-0290
• ISSN: 0006-3592
• Language: English
• Keywords: bax; Bcl-2; NOS; Bcl-xL; myeloma; apoptosis