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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

Abstract:

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2606

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Journal:
Nature genetics
Volume:
45
Issue:
5
Pages:
501-512
Publication date:
2013-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:8a3e825b-a130-4c3b-a0a1-f85d1e650573
Source identifiers:
394885
Local pid:
pubs:394885

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