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Journal article

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes.

Abstract:

OBJECTIVE: IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3'-UTR of IKZF1 with C-ALL susceptibility, we tested whether IKZF1 is associated with the autoimmune disease type 1 diabetes. RESEARCH DESIGN AND METHODS: rs10272724 (T>C) near IKZF1 at 7p12 was genotyped in 8,333 individual...

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Publication status:
Published

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Publisher copy:
10.2337/db10-0446

Authors


Journal:
Diabetes
Volume:
60
Issue:
3
Pages:
1041-1044
Publication date:
2011-03-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Language:
English
Keywords:
Pubs id:
pubs:445323
UUID:
uuid:8a34495e-029a-4b09-bf9a-f373815567c9
Local pid:
pubs:445323
Source identifiers:
445323
Deposit date:
2014-02-08

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