- Abstract:
-
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-mobilizing messenger that in many cells releases Ca(2+) from the endolysosomal system. Recent studies have shown that NAADP-induced Ca(2+) mobilization is mediated by the two-pore channels (TPCs). Whether NAADP acts as a messenger in astrocytes is unclear, and downstream functional consequences have yet to be defined. Here, we show that intracellular delivery of NAADP evokes Ca(2+) signals from acidic organelles in rat a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.c110.216580
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 286
- Issue:
- 32
- Pages:
- 27875-27881
- Publication date:
- 2011-08-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:8a2e0f55-f770-47cd-9c95-d4ae1f3d63a6
- Source identifiers:
-
373667
- Local pid:
- pubs:373667
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes.
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