Journal article
Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria.
- Abstract:
-
BACKGROUND: Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered. This could lead to imprecise estimates of the target PK parameters, and/or designs insufficient to estimate all of the parameters. Optimal design methodology has been developed to determine blood sampling schedules that wil...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Malaria Journal Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 181
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1475-2875
- ISSN:
-
1475-2875
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8a2da9d0-c043-45d6-a455-aa7c1caa1dd9
- Local pid:
- pubs:163963
- Source identifiers:
-
163963
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Jamsen et al
- Copyright date:
- 2011
- Notes:
- © 2011 Jamsen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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